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This figure depicts the process of cohort construction, detailing the inclusion and exclusion criteria applied to build the study cohorts for patients treated with GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors
By using 18 F-FDG as a contrast agent, PET-CT technology was used to reflect changes in body metabolism through the uptake of the contrast agent by the lesion, where 18 F-FDG is a glucose analog that indicates the degree of glucose uptake and is generally used clinically to quantify tissue metabolism (Paydary et al., 2019)
As of the end of March, there were 99 hospitalizations and seven deaths
The transition of cellular metabolism towards glycolysis is closely related to the inflammatory activation of microglia, which can trigger neuroinflammation and neuronal cytotoxicity [129]
