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Elevated extracellular lactate, a defining feature of the tumor microenvironment, predicts poor outcomes, and high GPR81 expression correlates with poorer survival (8,53,54)
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Detection Principle GDH catalyzes the dehydrogenation of glutamate, meanwhile, NAD+ is reduced to NADH, Which under the action of hydrogen transmitter, transfer electrons to WST-8 to produce the yellow product
The overall rate of GSH synthesis is controlled by several factors including: (i) availability of the substrate mainly L-cysteine (Taylor et al., 1996)
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