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2013 meta-analysis: A meta-analysis of 13 clinical trials including 3,629 adults with acute myocardial infarction who took L-carnitine (from 2.7 g/day for 5 days to 6 g/day for 12 months) versus placebo found that L-carnitine significantly reduced rates of all-cause mortality, ventricular arrhythmias, and new-onset angina

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We rated the certainty for each comparison and outcome as high, moderate, low, or very low, taking into consideration the risk of bias [26], inconsistency [27], imprecision [28, 29], indirectness [30], and publication bias [31]

It's also important for patients to have realistic expectations about the results and to understand that these medications are most effective when used in conjunction with lifestyle changes, including diet and exercise