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However, liraglutide treatment failed to show significant improvement of the UACR and eGFR trajectory in comparison to placebo ( The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) study assessed the CV outcome of liraglutide (1.8 mg) in comparison to placebo (Marso et al., 2016b)

These findings reveal that adipocyte circadian disruption impairs metabolic health through mitochondrial complex I dysfunction, establishing clock control of complex I as a key regulator of metabolic homeostasis

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