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In the ECHO-202/KEYNOTE-037 trial, epacadostat combined with the PD-1 inhibitor perbrolizumab showed extensive anti-tumor activity against a variety of cancer types (Mitchell et al., 2018)
The resulting disulfide in the Grx active site, however, is not reduced by a dedicated reductase, but by two molecules of GSH that reduce the Grx via a Grx active site and GSH (Grx-S-SG) mixed disulfide intermediate (Figure 1)
Combining peptides that work through different mechanisms can produce additive or synergistic effects
The ratio of review articles to original studies is something like two to one in 2026
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