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These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients
Wound healinga tightly coordinated cascade involving keratinocytes, macrophages, fibroblasts, and endothelial cellsrequires robust angiogenesis during the proliferative phase to establish a nutrient/oxygen supply via granulation tissue vascularization [12, 15]
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