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This impairs capillary integrity, allowing peripheral iron, lymphocytes, and cytokines to infiltrate the brain parenchyma, thereby amplifying local inflammation and iron dysregulation ( Moreover, ferroptosis-associated damage molecules such as high mobility group box-1 (HMGB1) and chemokine CXCL2 can directly impair the functional stability of brain microvascular endothelial cells
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What the research supports: Semaglutide (GLP-1 medication): Clinical trials show meaningful average weight loss for many people when used with lifestyle support and medical monitoring
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