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Among patients with baseline BMI of 35 or higher, discontinuation rates due to adverse events were 8.8% and 12.1% for the two doses compared to 4.8% with placebo

When GLP-1 binds to these receptors, it directly influences their function: Macrophages: GLP-1s can shift macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, reducing inflammation in tissues like fat