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8,9,37 These data provide robust evidence for the benefit of tirzepatide in patients with obesity and HFpEF

The FDA's stated reasoning is that there's no clinical need for outsourcing facilities to compound these drugs from bulk substances when FDA-approved versions exist

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Finally, studies published prior to 2018 were included only if they provided foundational pharmacokinetic or pharmacodynamic data on GLP-1 receptor distribution in the CNS or on the initial development of acylated GLP-1 analogs