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These typically improve over time as your body adjusts: Nausea Vomiting Diarrhea Constipation Stomach pain Decreased appetite Serious but Rare Side Effects These occur in less than 1% of patients but require immediate medical attention: Pancreatitis (pancreas inflammation) Gallbladder problems Kidney problems Severe allergic reactions Changes in vision Low blood sugar Severe stomach problems Cancer, whether thyroid or pancreatic, does not appear to be a significant risk based on current human research