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In addition to treating T2DM, metformin modestly reduces body weight gain, which may be achieved by upregulating growth differentiation factor 15 (GDF15) (Day et al., 2019

Past studies in mice linked the activation of GLP-1 receptors to alterations in sweet taste perception, but researchers were surprised to see that the effect in humans was broader than anticipated, says Richard Doty, director of the Smell and Taste Center at the University of Pennsylvania and co-author of the March paper

Reduced LDL (bad) and total cholesterol