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Eli Lilly recommends using a barrier method or non-oral contraception for at least 4 weeks after starting tirzepatide and for 4 weeks after each dose increase
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Interestingly, a tight bi-directional interaction of L cells and enterochromaffin cells has been described, with L cells expressing serotonin receptor 4 (51) and enterochromaffin cells expressing GLP-1 receptor (52)
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