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De Marinis L et al

Most individuals using Wegovy with a reduced-calorie diet and increased physical activity can expect to lose at least 5% of their initial body weight during the first three months of treatment

Dr Jarred Younger, a prominent researcher in neuroinflammation and chronic pain, has publicly stated that semaglutide does reduce chronic pain via these three pathways, but also acknowledged that all the semaglutide and microglia studies I know of are in animal models theres still another step that needs to be taken. That caveat matters enormously, and its one well come back to

By directly inhibiting this receptor, GLP-1 compounds reduced pain signaling at the most fundamental level