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Importantly, the role of PKA in activating multiple downstream targets involved in prosurvival signaling (eNOS, AKT) is well established (4, 21, 5054)
The simultaneous activation of GIP and GLP-1 receptors may have central synergistic effects on appetite control, greater than selective GLP-1 receptor agonists [55], although preliminary studies do not support this hypothesis [56]
By detoxifying excess of ROS, such interventions aim to restore redox balance, improve mitochondrial function, and ultimately enhance clinical outcomes
van der Griend R, Biesma DH, Haas FJ, Faber JA, Duran M, Meuwissen OJ, and Banga JD (2000)
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