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Early studies on Gly-His-Lys (GHK), first discovered in human plasma in the 1970s, demonstrated their ability to modulate gene expression, stimulate collagen synthesis, and accelerate wound healing, sparking broad interest in these bioactive molecules [23]

Protects cells from oxidative stress Preventing further damage and accelerating recovery

The localized ischemic and hypoxic environment in brain tissue, along with the release of cytotoxic substances and the accumulation of inflammatory mediators due to tissue damage in CVD, creates favorable conditions for lactate accumulation, thereby supporting the rationale for lactylation research

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