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This was evident when comparing exenatide and semaglutide chromatographic profiles: exenatide, a non-lipidated peptide with several acidic residues, was strongly affected by NSA (likely due to ionic and dipole-ionic interactions with metal surfaces), leading to decreased efficiency
These logistics are manageable but represent a real difference in daily treatment burden between an oral pill and an injectable biologic
Semaglutide is shown to help reduce appetite, which can be beneficial for those who struggle with overeating or frequent food cravings
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