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The compound's triple agonist mechanism may be considered sufficiently comprehensive that additional combinations aren't prioritized in the development pipeline
Indirect Calorimetry and Respiratory Exchange Ratio Indirect calorimetry estimates energy expenditure and substrate use from oxygen consumption and carbon-dioxide production
In addition, mitochondria are also the primary producers of intracellular reactive oxygen species (ROS), most of which originate from the mitochondrial respiratory chain [55]
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