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For instance, the AGE-RAGE signaling pathway is believed to induce the expression of proinflammatory modulators (IL-6, TNF- , IFN- ) via activation of the transcription nuclear factor kappa-B (NF-B) (15)
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Their work showed that restoring MST1 expression activates p53, which subsequently phosphorylates Drp1 at Ser616 to facilitate mitochondrial fission while concurrently suppresses Parkin transcription (61)
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