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Inflammatory cytokines contribute to brain endothelial cell activation and downregulation of tight junction proteins, such as zonula occludens-1 and claudin-5, resulting in bloodbrain barrier dysfunction [55]

Employers can stay ahead of the GLP-1 curve by proactively evaluating coverage strategies and vendors, monitoring utilization trends, and leveraging data-driven insights to manage costs effectively in 2025 and beyond.

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potentially complementary effects Interaction research: No published studies evaluate interactions between these compounds Risk: Unknown synergistic or antagonistic effects