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As weight loss with any existing pharmaceutical intervention inevitably plateaus due to putative counterregulatory mechanisms, we further hypothesized that the postulated enhanced body weight suppressive effects of combined amylin- and GLP-1R-based pharmacotherapies could be even further enhanced if the drugs were introduced in a stepwise fashion, allowing the physiological systems to adjust to and overcome the tachyphylaxis that occurs with repeated drug treatments 21,22,23
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Rams' Heat-Stress Assessment The temperature ( T ) and relative humidity (RH) at each time point during the study were over 36C and 60%, respectively, according to the Egyptian meteorological authority (Cairo, Egypt)
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