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Nutrients 14 , 1509 (2022)
Macrophage model research reports reductions in TNF- expression following KPV treatment
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It is mediated by specific signaling molecules, notably, including receptor-interacting protein kinases 1 and 3 (RIPK1 and RIPK3) and mixed lineage kinase domain-like protein (MLKL), which drive necroptosis by activating related signaling pathways in response to severe stress or pathological stimuli (Galluzzi et al., 2018)
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