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Efferent pathways from the brain to the heart originate within the central autonomic network (CAN), an anatomically and functionally defined network comprising cortical, subcortical, brainstem, and spinal regions that integrates central and peripheral nervous system input (Figure 1, ( Figure 1 2.1.1 Anatomy and clinical relevance of the CAN 2.1.1.1 Cortical structures The cortical component of the CAN play a fundamental role in modulating autonomic activity during emotional and cognitive processes ( The insular cortex (insula) is a key CAN component functionally linked to the limbic system, located within the lateral sulcus beneath the frontal, parietal, and temporal lobes
Para evitar la prdida de peso no deseada y los efectos secundarios gastrointestinales de los GLP-1, Kaufman suele empezar con una dcima parte de la dosis inicial estndar de 2.5 miligramos
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