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These numbers are lower than the clinical trials because real-world patients are less adherent, have more comorbidities, and may not reach the maximum dose
A 2025 University of Virginia study concluded that while GLP-1 drugs significantly reduce body weight and adiposity, they do so "with no clear evidence of cardiorespiratory fitness enhancement"a critical finding given that cardiorespiratory fitness is among the most potent predictors of all-cause and cardiovascular mortality [48]
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