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F-actin, organized into a dense actin barrier at the plasma membrane, impedes rapid exocytosis of insulin-containing LDCVs 3
This is thought to be mediated by direct GLP-1 receptor stimulation in the sinoatrial node
Because people respond differently to obesity medications, some may experience limited weight loss or may not tolerate current highly effective incretin-based therapies
They had found seven healthy volunteers to hook up to IV bags containing a solution of GLP-1
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