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PC deficiency reduces acetylcholine production, contributing to Alzheimer's disease and cognitive decline
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This strategy also coordinates downstream cyclic nucleotide-dependent cascades, including PKA-mediated phosphorylation of ERK, CREB, and DARPP-32, optimizing synaptic plasticity, neuronal excitability, and behavioral outcomes, and providing a rationale for comprehensive symptom management with reduced off-target effects
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