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In vivo, GCLC overexpression significantly mitigated MPTP-induced motor deficits and dopaminergic neuron loss in mouse models
GSH is one of the body's principal antioxidant defense molecules, playing a crucial role in the detoxification of cytotoxic compounds and reactive oxygen species.10 Intracellular GSH concentrations differ among tissues, typically ranging from 1 to 10 mM, with the highest levels observed in the liver.11 Experimental supplementation of GSH in animal models has been shown to reduce hepatocyte apoptosis, lower plasma AST and ALT activities, and protect against microvascular reperfusion injury.12 Melatonin (Mel) is a hormone primarily secreted by the pineal gland, but it is also synthesized in various tissues, including the ovaries, retina, lens, bone marrow, and gastrointestinal tract.13 In the retina and gastrointestinal system, it plays roles in visual adaptation and oxidative protection, respectively
In conclusion, the research outcomes of this novel initiative are likely to enhance the quality of life for individuals suffering from AD.
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