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The solute carrier family 5 member 8 (SLC5A8) is considered the primary butyrate transporter across the apical membrane of the colonocytes ( Butyrate and liver metabolism The liver is the master organ for regulating energy homeostasis, particularly for lipid and glucose metabolism regulation

The majority of participants were female (77.6%) and white (93.1%), with an average age of 47.3 (standard deviation: 11.0) years, a body mass index of 38.5 (standard deviation: 6.9) kg m2, and a weight of 106.0 (standard deviation: 22.0) kg

Similarly, dysregulated phosphatidylinositol 3-kinase (PI3K)/AKT signaling is associated with obesity and insulin resistance (Li et al