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In PIONEER 2, patients were receiving metformin monotherapy before randomization, whereas patients were receiving metformin with or without a sulfonylurea in PIONEER 3, and metformin with or without an SGLT-2 inhibitor in PIONEER 4
In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (McClean and Holscher, 2014
If youve been following medications like Ozempic , Wegovy , or Zepbound (tirzepatide) , you know they belong to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs)
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