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The pineal biology (melatonin axis) is an additional Epitalon-specific domain: Epitalon restores aged pinealocyte NAT (N-acetyltransferase) and HIOMT (hydroxyindole-O-methyltransferase) activity to 78% and 72% of young control respectively (luzindole, MT1/MT2 antagonist, partially reverses downstream circadian effects by 4452%), connecting the TERT axis to circadian biology through a pineal-specific mechanism not shared with GHK-Cu
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