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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )
That is the single most notable line in the readout, because gastrointestinal burden is the standard limiting factor across this drug class
Tests like serum B12 levels and methylmalonic acid (MMA) tests help
The combination is safe and potentially synergistic
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