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The guidelines further state that 5-ARIs are appropriate and effective alternatives for men with LUTS secondary to BPH who have demonstrable prostate enlargement
Comprehensive exercise achieves maximal effects by combining moderate-to-high intensity aerobic loads with explicit cognitive tasks, thereby activating neurotrophic factor pathways (e.g., the BDNF pathway) and the prefrontal executive function network (Longfei et al., 2025
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