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Therapeutic implications: context-specific applications The efficacy of antiangiogenic therapies is highly dependent on their application in the appropriate pathological contexts
Providers should transition to emerging weight loss peptides when a patient experiences intractable side effects (like severe nausea or gastroparesis), when they hit a hard weight loss plateau despite dietary compliance, or when the primary clinical obstacle is documented cellular metabolic resistance rather than hyperphagia (overeating)
Statistical analysis Sample sizes for single-nucleus transcriptomics and DREADD experiments were determined based on prior experience with similar paradigms 12,13
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