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Moving forward, the most realistic near-term translational path lies in combining relatively simple, biocompatible bone-targeted nanocarriers (such as alendronate-functionalized liposomal or polymeric systems) to specifically co-deliver immunogenic cell death (ICD)-inducing standard chemotherapeutics alongside established immune checkpoint inhibitors (e.g., anti-PD-1/PD-L1) or myeloid cell modulators
In predatory marine fish, approximately 90% of Hg is methylated (methylmercury), while the remainder consists of minimal amounts of inorganic mercury, ethylmercury, and phenylmercury (4)
Blood samples were collected on day 143 ante injectionem (ai) , day 11 ai , 24 hours post injectionem ( pi ), and day 14 pi and PBMC were isolated
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