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Furthermore, it provides a critical appraisal of recent human observational data, distinguishing metabolic benefits from intrinsic disease-modifying effects, and outlines the practical clinical friction points and prospective trials necessary to validate these pathways in future treatment paradigms

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It is crucial to understand that semaglutide's effects on insulin resistance are largely mediated through weight reduction and improved glycemic control rather than direct insulin-sensitizing action like metformin or thiazolidinediones

Great sources include apples, bananas, oats, nuts, and sweet potatoes