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No, Ipamorelin is a highly selective secretagogue engineered to stimulate growth hormone release without significantly spiking the cortisol or prolactin levels that disrupt the HPA axis

Davies MJ, Merton K, Vijapurkar U, Yee J, Qiu R

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Mechanistic pathways linking semaglutide to vaginal symptoms Indirect pathway through GI adverse effects and dehydration Both U.S