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This diurnal cortisol rhythm is essential for feeling rested, alert, and emotionally regulated

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Second, the TTH sample ( n = 19) may have been underpowered to detect subtle GSH alterations, and the conclusion that GSH reduction is specific to migraine should be interpreted cautiously pending replication with larger TTH cohorts that account for potential heterogeneity (e.g., episodic frequency, coexisting conditions)