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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

Receptor-independent effects of melatonin in EC: Melatonin enhances cellular immunity by increasing IL-2, IL-10, and interferon- (INF- ) release