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Safety Considerations with Metformin and DPP-4 Inhibitor Combination Each antihyperglycemic agent has a well-characterized riskbenefit profile that will need to be considered along with existing comorbidities (e.g., CVD, history of pancreatitis and/or pancreatic cancer, degree of renal dysfunction) when deciding on an appropriate therapeutic regimen
They can be overly broad, and do not account for a dogs body composition if overweight or underweight
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If the powder still has not dissolved after refrigeration, the peptide may have been damaged during lyophilization or shipping, rendering it partially insoluble
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