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The best medication is the one that you can take consistently with manageable side effects

Nausea (25-60%), vomiting, diarrhea, and constipation are typical

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The presence of increased levels of oxidized dopamine and lower glucocerebrosidase activity, in turn promotes S accumulation ( Although direct interconnections between the release of pro-inflammatory cytokines and S accumulation have yet to be established, altered pro-inflammatory cells in experimental PD models suggest that inflammation and S dysregulation are closely interconnected (Tan et al., 2020)