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Some real-world cohorts and long-term extension trials have reported comparable efficacy of biologic agents across BMI categories, especially when weight-based dosing regimens or dose optimization strategies were applied
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For weight management, combining GLP-1 receptor agonists with other anti-obesity medications is generally considered off-label with limited evidence and should be directed by specialists
Those with a history of alcohol dependence should discuss whether weight loss injections are appropriate and receive support for maintaining sobriety
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