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Catalpol has considerable antioxidant and anti-inflammatory activities, decreasing endothelial dysfunction and reducing free radical generation via inhibiting Nox-4 and increasing superoxide dismutase (SOD) [316]
Large cardiovascular outcome trials have also demonstrated that several GLP-1 agents reduce major adverse cardiovascular events
This review synthesizes current evidence linking microbiota alterations to Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and strokeincluding post-stroke cognitive impairment (PSCI), as well as major depressive disorder (MDD), bipolar disorder (BD), anxiety disorders, post-traumatic stress disorder (PTSD), and chronic fatigue syndrome (CFS)
The Muscle Loss Problem Data from the landmark STEP 1 trial (semaglutide 2.4mg) and the SURMOUNT-1 trial (tirzepatide) revealed that lean soft tissue loss comprised 26-40% of total weight lost
