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Participants receiving Glutathione rather than a saline solution placebo were given intravenous infusions two times daily for five days and then analyzed for mobility
The molecule retains the complete 70-amino-acid native IGF-1 sequence with two structural modifications a 13-amino-acid N-terminal extension (the Long designation) and an arginine-for-glutamic-acid substitution at position 3 (the R3 designation) which together reduce binding affinity to circulating IGF binding proteins (IGFBPs) by approximately 600-fold while preserving full agonist activity at the IGF-1 receptor
Lancet 349 : 397397
Importantly, while the incidence of adverse effects was similar between ALC and placebo/no intervention, ALC was associated with a lower incidence of adverse effects compared to antidepressant medications
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