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integrated spatial metabolomics (SM) and spatial transcriptomics (ST) in nasopharyngeal carcinoma, revealing enhanced branched-chain amino acid (BCAA) metabolic activity enriched in tumor regions and colocalized with immune cells

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Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity

"Transforma Page 90 and 91: Choi K, Kim Y, Park J, Park CK, Kim Page 92 and 93: Chung H-H, Lee J-B, Chung Y-H, and Page 94 and 95: 106(34):14728-14733