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To increase the stability of GLP-1R, the fusion protein rubredoxin was inserted into intracellular loop 2 (ICL2) of GLP-1R between positions 257 to 262 and 11 mutations were introduced
Blocking histamine activity can boost appetite, as noted with several other drugs that cause weight gain
Patients with stage I, II, or III BC were included, while those with stage IV BC, prior malignant neoplasms, or metastatic disease were excluded
Each follow-up should include weight and body composition measurements, medication review and dose adjustment, dietary compliance assessment, and side effect evaluation
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![PDF] Tirzepatide-Induced Injection Site Reaction](https://figures.semanticscholar.org/18fb0b8dbc04c04a7b5177d9fd87256fc7c060bb/2-Figure1-1.png)
