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JPMorgan's Schott said tolerability is the "key focus" for doctors, patients, and investors examining orforglipron's phase 3 data, with a goal of nausea rates below 25% and vomiting rates in the low double digits for diabetes patients

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Only 34% of GLP-1 patients on DPP-4 inhibitors, a class of oral diabetic medications also known as gliptins, were still taking DPP-4 inhibitors 52 weeks after starting GLP-1 therapy according to Earnest pharmacy claims data