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Alcohol acts on neurotransmitter receptors, including GABA, glutamate, and dopamine, with each receptor contributing to various physiologic effects, with chronic alcohol administration increasing tolerance and addiction ( The brains of individuals with alcohol dependence have increased proinflammatory cytokines, chemokines, microglial markers, and inflammasome proteins ( Brain microvascular endothelial cells (BMVEC) are interconnected with TJ to form a tight monolayer in the BBB

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Hormones, sunlight, and certain chemicals can also affect melanin production