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Ozempic (brand-name semaglutide) costs $9001,200 monthly without insurance, though compounded semaglutide from 503B pharmacies typically costs $250400 monthly
Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility
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