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Statistical analysis Statistical analyses were performed using R version 3.3.0 for Windows (The R Foundation for Statistical Computing, Vienna, Austria)

Another clinical study showed participants with DPN underwent nerve ultrasonography, neuropathy symptom scoring, and nerve conduction studies before and after one month of GLP-1RA therapy (semaglutide or dulaglutide) [89]

Appetite reduction usually begins within the first few days Mild GI side effects are most common during this period Weight loss of 2-5 pounds is typical Energy levels may fluctuate Weeks 5-12: Building Momentum As your dose is titrated upward, effects become more pronounced

Because of this dual-pathway approach, many patients experience faster weight loss, stronger appetite control, and improved metabolic response