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Secondary pharmacodynamic (PD) endpoints for warfarin were the maximum observed INR from time zero to 144 h after dosing (INR max ), the incremental area under the INR responsetime curve from time zero to 144 h (iAUC 0 144h,INR ), and the time to maximum INR (t INR,max )
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This plateau is normal physiology and does not indicate the medication has stopped working
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