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For suspected macro-B12, precipitation with PEG is the test most often reached for, though it is nonspecific and can remove B12 that is fully available to cells, so direct measurement of the binding proteins, haptocorrin and transcobalamin, may be more informative when it is available

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Each dose should be spaced at least four hours apart to prevent inadvertent accumulation

This is why cleanser for clear skin is essential to maintain the balance on the skin